Center for Reproductive Health Research Studies
If you are unsure about what studies you qualify for, simply email us at [email protected]. Alternatively, explore different UCSF studies at clinicaltrials.ucsf.edu.
Intrauterine Insemination (IUI) Studies
FIT-Plese Study | Improving Reproductive Fitness through Pretreatment with Lifestyle Modification in Obese Women with Unexplained Infertility
Status: Active, Enrolling
A two-arm, multicenter, prospective, randomized clinical trial of a lifestyle modification program with tracked increased physical activity and weight loss (intensive) compared to recommendations to tracking of increased physical activity alone with weight maintenance (standard) in women with obesity and unexplained infertility.
You may be eligible if you are: female (or assigned female at birth), aged 18-40, have a BMI over 30, and experiencing one or more years of infertility
Alex McGough
Clinical Research Coordinator
415-502-2557
[email protected]
Marcelle Cedars MD
Principal Investigator
In Vitro Fertilization (IVF) Studies
3M Study | Media, Morphokinetics and Mosaicism Study
Status: Active, Enrolling
The purpose is to determine if two different, both commercially-available, embryo culture media’s impact 1) the development of embryos 2) the likelihood of an embryo having normal chromosome numbers (Euploid). The two different medias contain nutrients that help to support the cell of the embryo – both medias are in use in IVF laboratories throughout the United States.
You may be eligible if you are: a male-female couple, aged 18 years or older, and undergoing IVF with planned Preimplantation Genetic Screening (PGS)
Flor Juarez
Clinical Research Coordinator
415-514-6387
[email protected]
Mitchell Rosen MD HCLD
Principal Investigator
CHIP Study | Sperm Selection by Microfluidic Separation Improves Embryo Quality in Patients with a History of Poor Embryo Quality
Status: Active, Enrolling
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility. Couples will be randomized to sperm selection by the clinical standard of centrifugation and density-gradient processing compared to the microfluidic sperm sorting chip.
You may be eligible if you are: a male-female couple, aged 18 years or older, and undergoing IVF or ICSI treatment
Flor Juarez
Clinical Research Coordinator
415-514-6387
[email protected]
Mitchell Rosen MD HCLD
Principal Investigator
CLeAR Study | Cytokines, Lipids, and Reproduction (CLeAR) Study
Status: Active, Enrolling
The CLeAR study is investigating markers of inflammation and reproductive health. Inflammation may influence human fertility and we would like to know more about these factors and evaluate the impact of these markers on various stages of reproduction. Participants will be asked for a short blood draw and follicular fluid collection (typically discarded during IVF) during their retrieval procedure.
You may be eligible if you are: female, aged 18-43 years old, and undergoing in vitro fertilization (IVF) treatment
Alex McGough
Clinical Research Coordinator
415-502-2557
[email protected]
Victor Fujimoto MD
Principal Investigator
DESCRT Study | Developmental Epidemiological Study on Children born through Reproductive Technology
Status: Active, Enrolling
Despite the rise in the number of births from fertility treatments, there are limited long-term data on health of the offspring. The purpose of the study is to establish an epidemiological cohort of almost 4,000 pregnancies to address critical public health questions regarding potential metabolic risk to children conceived through fertility treatments.
You may be eligible if you are: have previously/are currently receiving fertility treatment from UCSF Center of Reproductive Health
Maria Lara
Clinical Research Coordinator
415-476-3798
[email protected]
Marcelle Cedars MD
Principal Investigator
INVOcell Study | Intravaginal Culture of Embryos
Status: Active, Enrolling
The purpose of this study is to evaluate implantation rate with intra-vaginal culture with the INVOcell device versus traditional IVF while using minimal stimulation protocols.
You may be eligible if you are: female (or assigned female at birth), aged 18-37, and experiencing one or more years of infertility
Nik Lenhart
Clinical Research Coordinator
415-502-2555
[email protected]
Marcelle Cedars MD
Principal Investigator
hESC Study | Human Embryonic Stem Cell Study
Status: Active, Enrolling
The study is enrolling UCSF CRH patients willing to donate embryos created during the IVF cycle that are of low quality and therefore cannot be used for treatment. Embryos to used in this project would normally be discarded because their quality indicates that they cannot implant and subsequently cannot give rise to pregnancy. The overall goal of the study is to develop cell-based therapies for diabetes.
You may be eligible if you are: female (or assigned female at birth), aged 18-41, undergoing IVF treatment at UCSF Center for Reproductive Health, and not using sperm or ovum donor samples
Shani Litwin
Clinical Research Coordinator
[email protected]
Susan Fisher PhD
Principal Investigator
Michael McMaster PhD
Principal Investigator
Paolo Rinaudo MD
Study Clinician
Low Dose Study | Administration of FSH and Low Dose hCG for Oocyte Maturity while Decreasing hCG Exposure in IVF Cycles
Status: Active, Enrolling
This is a randomized, double-blind, single center clinical trial study to compare the oocyte maturity, embryo development, and risk of ovarian hyperstimulation syndrome (OHSS) after receiving the standard dose of human chorionic gonadotropin (hCG) ovulation trigger or a lower dose of hCG plus concomitant follicle stimulating hormone (FSH) co-trigger in women undergoing in vitro fertilization (IVF).
You may be eligible if you are: female (or assigned female at birth), aged 18-40, and beginning IVF treatment at UCSF Center for Reproductive Health
Flor Juarez
Clinical Research Coordinator
415-514-6387
[email protected]
Mitchell Rosen MD HCLD
Principal Investigator
PrISICE Trial | Pre-Implantation Screening and Investigation on the Cryopreservation of Embryos
Status: Active, Not Enrolling
The trial objective is to determine whether the deferred transfer of embryos following cryopreservation at the blastocyst stage following pre-implantation genetic screening (PGS-FET) improves live birthrates compared to both the deferred transfer of cryopreserved embryos without PGS (FET) and immediate transfer at the conclusion of a "fresh" in vitro fertilization (IVF) cycle (Fresh).
You may be eligible if you are: female (or assigned female at birth), aged 18-42, and undergoing IVF treatment
Alex McGough
Clinical Research Coordinator
415-502-2557
[email protected]
Marcelle Cedars MD
Principal Investigator
Polycystic Ovarian Syndrome Studies
MINDD Study | Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) Trial
Status: Active, Enrolling
This clinical trial explores new options for treating depressed mood in women with PCOS, low Vitamin D and insulin resistance. Participants will complete psychological questionnaires and have blood testing. They will be randomly assigned to one of two treatments (Vitamin D or Metformin). Mood and blood testing is repeated after the 12-week trial, and participants will have an individualized follow-up visit with the study doctor to wrap-up.
You may be eligible if you are: female (or assigned female at birth), aged 18-45, diagnosed with PCOS, presence of insulin resistance and low Vitamin D
Alex McGough
Clinical Research Coordinator
415-502-2557
[email protected]
Heather Huddleston MD
Principal Investigator
clinical trials Website
For more information or additional PCOS related studies, please visit our PCOS clinic website.
PCOG Study | Insulin Resistance and Cognitive Function in Polycystic Ovary Syndrome
Status: Active, Enrolling
This study investigates relationship between insulin resistance, mood and cognitive function in PCOS. Participants will have a blood glucose testing to determine insulin and glucose levels and will meet with a trained specialist for a cognitive assessment visit. The cognitive assessment visit will include modules looking at domains such as mood, executive functioning, memory, and reasoning, which are associated with common PCOS symptoms like brain fog.
You may be eligible if you are: female (or assigned female at birth), aged 18-45, and diagnosed with PCOS
Alex McGough
Clinical Research Coordinator
415-502-2557
[email protected]
Heather Huddleston MD
Principal Investigator
PCOS Clinic Website
For more information or additional PCOS related studies, please visit our PCOS clinic website.
PCOS Exercise Study | Effects of Exercise on Polycystic Ovary Syndrome
Status: Active, Enrolling
This study is determining which type of exercise, vigorous for a short duration or moderate for a longer duration, will help patients with PCOS most in improving insulin resistance, BMI, metabolic profiling, and mood symptoms. Participants will be assigned to one of the two exercise regimens, meet with an exercise physiologist for a one-hour training session, and be provided with a FITBIT Fitness Tracker for the duration of the study.
You may be eligible if you are: female (or assigned female at birth), aged 18-50, diagnosed with PCOS and presence of insulin resistance
Alex McGough
Clinical Research Coordinator
415-502-2557
[email protected]
Heather Huddleston MD
Principal Investigator
PCOS Clinic Website
For more information or additional PCOS related studies, please visit our PCOS clinic website.
Paleo Diet Study | Paleo Versus Healthy ADA Diets for Treatment of Polycystic Ovarian Syndrome (PCOS)
Status: Active, Enrolling
This study is evaluating the effects of specific diets on the regulation of menstrual cycles in PCOS patients to help improve fertility treatments for women with PCOS. Participants will follow a paleolithic-type diet or a health ADA-recommended diet to see if either one can help regulate menstrual cycles. Participation will be supported by visits with a diet coach, social media activity, and teleconferences with investigators.
You may be eligible if you are: female (or assigned female at birth), aged 18-40, and diagnosed with PCOS
Alex McGough
Clinical Research Coordinator
415-502-2557
[email protected]
Heather Huddleston MD
Principal Investigator
clinical trials Website
For more information or additional PCOS related studies, please visit our PCOS clinic website.
PCOS Tissue Bank & Longitudinal Study
Status: Active, Enrolling
The purpose of this study is to explore the relationship between genetic and environmental factors that may explain PCOS. We will use information collected during visits to our PCOS clinic and the family history of PCOS patients to learn about the causes and effects of PCOS.
You may be eligible if you are: female (or assigned female at birth), aged 18 years or older, and diagnosed with PCOS
Alex McGough
Clinical Research Coordinator
415-502-2557
[email protected]
Heather Huddleston MD
Principal Investigator
PCOS Clinic Website
For more information or additional PCOS related studies, please visit our PCOS clinic website.
Reproductive Health Management Studies
OVA.CV Study | Longitudinal Evaluation of Ovarian Aging and Cardiovascular Risk
Status: Active, Not Enrolling
The Ovarian Aging (OVA) cohort is the largest and most ethnically diverse, community-based cohort available that can be used to determine the race/ethnic and behavioral determinants of ovarian aging and its association with CVD risk in a young cycling population. The purpose of the study is to use a longitudinal approach to evaluate markers of ovarian and cellular aging as predictors of CVD, and potentially develop new risk-reduction strategies.
We are currently not accepting any new participants.
Maritza Cárdenas
Clinical Research Coordinator
415-502-4492
[email protected]
English | Spanish
Yiu Ho Au
Clinical Research Coordinator
415-476-3514
[email protected]
English | Mandarin | Cantonese
PRP Study | Platelet Rich Plasma for Endometrial Regeneration and Repair
Status: Active, Enrolling
Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant clinical challenge. The aim of this trial is to assess if intrauterine administration of platelet rich plasma (PRP) improves endometrial lining thickness in patients with thin lining or Asherman's Syndrome.
You may be eligible if you are: female (or assigned female at birth), aged 18-42, and diagnosed with Asherman’s Syndrome
Nik Lenhart
Clinical Research Coordinator
415-502-2555
[email protected]
Heather Huddleston MD
Principal Investigator
ACTorNOT Study | Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location
Status: Active, Enrolling
This is a randomized controlled trial to compare three currently available management strategies for women with a persisting pregnancy of unknown location (PPUL), which makes them at-risk for ectopic pregnancy. Hemodynamically stable women with a confirmed PPUL will be randomized to one of three strategies: 1) Uterine evacuation followed by methotrexate (MTX) for some (those that have evidence of a non-visualized ectopic pregnancy) 2) Empiric treatment with MTX for all 3) Expectant management.
You may be eligible if you are: female (or assigned female at birth), aged 18 years and older, and diagnosed with a persisting pregnancy of unknown location (PPUL)
Nik Lenhart
Clinical Research Coordinator
415-502-2555
[email protected]
Marcelle Cedars MD
Principal Investigator
Fertility Preservation Studies
BRIOR Study | Impact of Local Radiotherapy to the Breast on Ovarian Reserve in Premenopausal Women with Early-Stage Breast Cancer
Status: Active, Enrolling
This study aims to prospectively assess the impact of distant effects from breast radiation on ovarian reserve. We will determine ovarian reserve through blood measurements of Anti-Müllerian Hormone (AMH), a relatively new and reliable serum biomarker of ovarian reserve that has already been incorporated into the standard practice of reproductive endocrinology and infertility.
You may be eligible if you are: female (or assigned female at birth), aged 18-45, and diagnosed with in-situ breast cancer or stage 1 breast cancer
Nik Lenhart
Clinical Research Coordinator
415-502-2555
[email protected]
Mitchell Rosen MD HCLD
Principal Investigator
PGS Perspectives Study | Patient Perspectives on Preimplantation Genetic Screening (PGS)
Status: Active, Enrolling
Patients will be asked to complete the one-time two minute survey in the waiting room at the time of a clinic visit for IVF (in-treatment cycle) or by e-mail invitation if they have a history of undergoing IVF at the UCSF Center for Reproductive Health.
You may be eligible if you are: a male-female couple, aged 18 years or older, and undergoing/undergone IVF at UCSF CRH since 2010
Flor Juarez
Clinical Research Coordinator
415-514-6387
[email protected]
Mitchell Rosen MD HCLD
Principal Investigator
TALES Trial | Fertility Preservation using Tamoxifen and Letrozole in Estrogen Sensitive Tumors Trial
Status: Active, Enrolling
Letrozole plus gonadotropin, and Tamoxifen plus gonadotropin, are two methods currently used worldwide in ovarian stimulation cycles for fertility preservation in patients with estrogen-receptor-positive breast cancer. Improved knowledge about the efficacy of these medications, with regard to oocyte yield, has the potential to significantly improve quality of life in reproductive-age breast cancer survivors.
You may be eligible if you are: female (or assigned female at birth), aged 18 years and older, diagnosed with breast cancer and not currently receiving chemotherapy
Nik Lenhart
Clinical Research Coordinator
415-502-2555
[email protected]
Mitchell Rosen MD HCLD
Principal Investigator